pentobarbital will lessen the extent or impact of artemether/lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration with sturdy CYP3A4 inducers can result in lowered serum concentrations and lack of antimalarial efficacy
pentobarbital will decrease the extent or impact of estropipate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital will decrease the extent or outcome of erlotinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
Monoamine oxidase inhibitors (MAOI): MAOI lengthen the results of barbiturates in all probability because metabolism on the barbiturate is inhibited.
pentobarbital will lessen the extent or impact of lumacaftor/ivacaftor by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
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fentanyl transmucosal and pentobarbital both boost sedation. Avoid or Use Alternate Drug. Limit use to individuals for whom substitute therapy options are insufficient
4. Appropriate with Loss of life in aged or sick individuals or in more info existence of obstructed airway, other harmful brokers, or publicity to chilly.
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pentobarbital will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Strong CYP3A4 inducers are envisioned to cause sizeable decreases in sildenafil plasma levels
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Phenobarbital has been shown to shorten the half-life of doxycycline for so long as two months just after barbiturate therapy is discontinued. This system might be from the induction of hepatic microsomal enzymes that metabolize the antibiotic.
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